Selected publications


Chemical exchange saturation transfer (CEST) MRI

Walker-Samuel S, Ramasawmy R, Torrealdea F, Rega M, Rajkumar V, Johnson SP, Richardson S, Gonçalves M, Parkes HG, Arstad E, Thomas DL, Pedley RB, Lythgoe MF, Golay X. In vivo imaging of glucose uptake and metabolism in tumors. Nat Med. 2013 Aug;19(8):1067-72.

Wells JA, O'Callaghan JM, Holmes HE, Powell NM, Johnson RA, Siow B, Torrealdea F, Ismail O, Walker-Samuel S, Golay X, Rega M, Richardson S, Modat M, Cardoso MJ, Ourselin S, Schwarz AJ, Ahmed Z, Murray TK, O'Neill MJ, Collins EC, Colgan N, Lythgoe MF. In vivo imaging of tau pathology using multi-parametric quantitative MRI. Neuroimage. 2015 May 1;111:369-78.

Walker-Samuel S, Johnson SP, Pedley B, Lythgoe MF, Golay X. Extracranial measurements of amide proton transfer using exchange-modulated point-resolved spectroscopy (EXPRESS). NMR Biomed. 2012 Jun;25(6):829-34. doi: 10.1002/nbm.1798.


tumour microstructure (diffusion MRI, IRON OXIDE NANOPARTICLES)

Panagiotaki E, Walker-Samuel S, Siow B, Johnson SP, Rajkumar V, Pedley RB, Lythgoe MF, Alexander DC. Noninvasive quantification of solid tumor microstructure using VERDICT MRI. Cancer Res. 2014 Apr 1;74(7):1902-12.

O'Callaghan J, Wells J, Richardson S, Holmes H, Yu Y, Walker-Samuel S, Siow B, Lythgoe MF. Is your system calibrated? MRI gradient system calibration for pre-clinical, high-resolution imaging. PLoS One. 2014 May 7;9(5):e96568.

Beloueche-Babari M, Jamin Y, Arunan V, Walker-Samuel S, Revill M, Smith PD, Halliday J, Waterton JC, Barjat H, Workman P, Leach MO, Robinson SP. Acute tumour response to the MEK1/2 inhibitor selumetinib (AZD6244, ARRY-142886) evaluated by non-invasive diffusion-weighted MRI. Br J Cancer. 2013 Sep 17;109(6):1562-9.

Burrell JS, Bradley RS, Walker-Samuel S, Jamin Y, Baker LC, Boult JK, Withers PJ, Halliday J, Waterton JC, Robinson SP. MRI measurements of vessel calibre in tumour xenografts: comparison with vascular corrosion casting. Microvasc Res. 2012 Nov;84(3):323-9.

Boult JK, Walker-Samuel S, Jamin Y, Leiper JM, Whitley GS, Robinson SP. Active site mutant dimethylarginine dimethylaminohydrolase 1 expression confers an intermediate tumour phenotype in C6 gliomas. J Pathol. 2011 Nov;225(3):344-52.

Walker-Samuel S, Boult JK, McPhail LD, Box G, Eccles SA, Robinson SP. Non-invasive in vivo imaging of vessel calibre in orthotopic prostate tumour xenografts. Int J Cancer. 2012 Mar 15;130(6):1284-93. 



Fryer RA, Graham TJ, Smith EM, Walker-Samuel S, Morgan GJ, Robinson SP, Davies FE. Characterization of a novel mouse model of multiple myeloma and its use in preclinical therapeutic assessment. PLoS One. 2013;8(2):e57641.

Boult JK, Terkelsen J, Walker-Samuel S, Bradley DP, Robinson SP. A multi-parametric imaging investigation of the response of C6 glioma xenografts to MLN0518 (tandutinib) treatment. PLoS One. 2013 Apr 26;8(4):e63024.

Boult JK, Jamin Y, Jacobs V, Gilmour LD, Walker-Samuel S, Halliday J, Elvin P, Ryan AJ, Waterton JC, Robinson SP. False-negative MRI biomarkers of tumour response to targeted cancer therapeutics. Br J Cancer. 2012 Jun 5;106(12):1960-6.

Baker LC, Boult JK, Walker-Samuel S, Chung YL, Jamin Y, Ashcroft M, Robinson SP. The HIF-pathway inhibitor NSC-134754 induces metabolic changes and anti-tumour activity while maintaining vascular function. Br J Cancer. 2012 May 8;106(10):1638-47.

Burrell JS, Walker-Samuel S, Baker LC, Boult JK, Jamin Y, Ryan AJ, Waterton JC, Halliday J, Robinson SP. Evaluation of novel combined carbogen USPIO (CUSPIO) imaging biomarkers in assessing the antiangiogenic effects of cediranib (AZD2171) in rat C6 gliomas. Int J Cancer. 2012 Oct 15;131(8):1854-62.


MRI measurement of blood flow and tumour oxygenation

Gonçalves MR, Johnson SP, Ramasawmy R, Pedley RB, Lythgoe MF, Walker-Samuel S. Decomposition of spontaneous fluctuations in tumour oxygenation using BOLD MRI and independent component analysis. Br J Cancer. 2015 Oct 20;113(8):1168-77.

Ramasawmy R, Campbell-Washburn AE, Wells JA, Johnson SP, Pedley RB, Walker-Samuel S, Lythgoe MF. Hepatic arterial spin labelling MRI: an initial evaluation in mice. NMR Biomed. 2015 Feb;28(2):272-80.

Rukat T, Walker-Samuel S, Reinsberg SA. Dynamic contrast-enhanced MRI in mice: an investigation of model parameter uncertainties. Magn Reson Med. 2015 May;73(5):1979-87.

Baker LC, Boult JK, Jamin Y, Gilmour LD, Walker-Samuel S, Burrell JS, Ashcroft M, Howe FA, Griffiths JR, Raleigh JA, van der Kogel AJ, Robinson SP. Evaluation and immunohistochemical qualification of carbogen-induced ΔR2 as a noninvasive imaging biomarker of improved tumor oxygenation. Int J Radiat Oncol Biol Phys. 2013 Sep 1;87(1):160-7.

Burrell JS, Walker-Samuel S, Baker LC, Boult JK, Jamin Y, Halliday J, Waterton JC, Robinson SP. Exploring ΔR(2) * and ΔR(1) as imaging biomarkers of tumor oxygenation. J Magn Reson Imaging. 2013 Aug;38(2):429-34.


Optical imaging

d'Esposito A, Nikitichev D, Desjardins A, Walker-Samuel S, Lythgoe MF. Quantification of light attenuation in optically cleared mouse brains. J Biomed Opt. 2015 Aug 1;20(8):80503. 

Schneider C, Johnson SP, Walker-Samuel S, Gurusamy K, Clarkson MJ, Thompson S, Song Y, Totz J, Cook RJ, Desjardins AE, Hawkes DJ, Davidson BR. Utilizing confocal laser endomicroscopy for evaluating the adequacy of laparoscopic liver ablation. Lasers Surg Med. 2015 [Epub ahead of print]


Contrast Agents

Hembury M, Chiappini C, Bertazzo S, Kalber TL, Drisko GL, Ogunlade O, Walker-Samuel S, Krishna KS, Jumeaux C, Beard P, Kumar CS, Porter AE, Lythgoe MF, Boissière C, Sanchez C, Stevens MM. Gold-silica quantum rattles for multimodal imaging and therapy. Proc Natl Acad Sci U S A. 2015 Feb 17;112(7):1959-64.

Kalber TL, Campbell-Washburn AE, Siow BM, Sage E, Price AN, Ordidge KL, Walker-Samuel S, Janes SM, Lythgoe MF. Primed infusion with delayed equilibrium of Gd.DTPA for enhanced imaging of small pulmonary metastases. PLoS One. 2013;8(1):e54903.


MRI phenotyping

Norris FC, Betts-Henderson J, Wells JA, Cleary JO, Siow BM, Walker-Samuel S, McCue K, Salomoni P, Scambler PJ, Lythgoe MF. Enhanced tissue differentiation in the developing mouse brain using magnetic resonance micro-histology. Magn Reson Med. 2013 Nov;70(5):1380-8.